ARD Podcast

Managing Systemic Lupus Erythematosus: the latest EULAR recommendations

This podcast brings you the 2023 update on the EULAR recommendations for the management of systemic lupus erythematosus (SLE).
ARD's Social Media Advisor, Professor Laura Andreoli, speaks to Professors Antonios Fanouriakis and Dimitrios Boumpas, both from the "Attikon" University Hospital, National and Kapodistrian University of Athens, Greece, two of the authors of the recommendations paper. Read it on the ARD website: https://ard.bmj.com/content/83/1/15.
Please subscribe to the ARD podcast on all podcast platforms, including Apple Podcast, Stitcher and Spotify. If you enjoy the show, feel free to leave us a comment or a review on the podcast iTunes page - https://podcasts.apple.com/gb/podcast/ard-podcast/id1171058059 .

A non-pharma approach in systemic lupus erythematosus and systemic sclerosis

In this podcast, we discuss the evidence-based EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).ARD's Social Media Advisor, Professor Laura Andreoli, speaks to Professor Carina Boström and Professor Ioannis Parodis, both from the Karolinska Institutet and the Karolinska University Hospital, Stockholm, Sweden, about their recent paper. Read it on the ARD website: https://ard.bmj.com/content/early/2023/08/23/ard-2023-224416
Please subscribe to the ARD podcast on all podcast platforms, including Apple Podcast, Google Podcasts, Stitcher and Spotify. If you enjoy the show, feel free to leave us a comment or a review on the podcast iTunes page -https://podcasts.apple.com/gb/podcast/ard-podcast/id1171058059 .
 

Innate Lymphoid Cells link TGFb and fibrotic pathways in systemic sclerosis skin

In this podcast, Dr. Truchetet discusses her work on the role of innate lymphoid cells in the fibrotic processes in systemic sclerosis (SSc) patients. The group of Dr. Truchetet found that ILC2 are crucial mediators of skin fibrosis in SSc and that combined treatment of patients with TGFb inhibitors and IL-10 might be an attractive new therapeutic approach in SSc.
Read the full paper on the ARD website: https://ard.bmj.com/content/80/12/1594
Please subscribe to the ARD podcast on all podcast platforms, including Apple Podcast, Google Podcasts, Stitcher and Spotify. If you enjoy the show, feel free to leave us a comment or a review on the podcast iTunes page (https://podcasts.apple.com/gb/podcast/ard-podcast/id1171058059).

Immunogenicity of anti-SARS-CoV-2 mRNA vaccines in patients with rheumatic diseases

In this podcast, we invite two authors from recent ARD papers dedicated to the efficacy of mRNA vaccines in patients with immunosuppressive therapies.
Christophe Richez, Department of Rheumatology, University Medical Center, Bordeaux, France, and ARD's Social Media Advisor, interviews Bimba Hoyer, Department for Rheumatology and Clinical Immunology, University Medical Center Schleswig-Holstein Campus Kiel, Germany, and Rebecca H Haberman, Division of Rheumatology, University Grossman School of Medicine, New York, USA. They describe their works and offer their thoughts on the current situation in this area and the future.
Related content:
https://ard.bmj.com/content/early/2021/05/11/annrheumdis-2021-220272
https://ard.bmj.com/content/early/2021/06/07/annrheumdis-2021-220597

The EULAR COVID-19 database and its insights into risk factors

The EULAR COVID-19 database and the COVID-19 Global Rheumatology Alliance work together on shared collected data to address the most pertinent questions in regard to risks for people with rheumatic diseases and COVID-19 infection. The latest study confirms already known risk factors for more severe disease and explores associations between treatments and the risk of death.
In this podcast, ARD’s social media editor, Dr Paul Studenic, is joined by Prof. Pedro Machado, from the National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre, London, UK, to discuss the paper “Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry” (http://dx.doi.org/10.1136/annrheumdis-2020-219498).

Predictors of disease worsening in systemic sclerosis

Capturing disease progression in SSc is challenging. Becker and colleagues addressed this problem by identifying predictors of disease worsening in the EUSTAR cohort. ARD's social media advisor Dr. Caroline Ospelt talks to Dr. Mike Becker about the results of this analysis.
Read the paper: ard.bmj.com/content/78/9/1242

Treating Cytokine Storm Syndrome in COVID-19 patients with glucocorticoids and tocilizumab

In this podcast, Dr. Paul Studenic speaks to Dr. Sofia Ramiro and Prof. Robert Landewé both engaged in clinical work in the Zuyderland Medical Center in the south of the Netherlands about their clinical study evaluating systemic glucocorticoids and Il-6 blockade as second-line treatment for COVID-19-associated cytokine storm syndrome. They tell the story of the set-up of a peculiar trial using historical patients treated with supportive care as controls to the ‘experimental’ treatment strategy during these unprecedented times of March and April 2020.
Link to article: https://ard.bmj.com/content/79/9/1143
Link to EULAR press release: https://www.eular.org/sysModules/obxContent/files/www.eular.2015/1_42291DEB-50E5-49AE-5726D0FAAA83A7D4/eular_glucocorticoids_and_il_6_receptor_can_reduce_covid19_css_related_hospital_mortality_(002).pdf

The dose dependent effect of statins on osteoporosis

Statins are some of the most commonly prescribed cholesterol-lowering drugs. They act by inhibiting HMG-CoA reductase, the main enzyme in the synthesis of cholesterol. Earlier studies have shown that statins have an osteoprotective effect: a recently published paper has shown that there is a dose-dependent relationship between different kinds of statins with diagnosis of osteoporosis. "We could find an underrepresentation of osteoporosis in low-dose and an overrepresentation in high-dose statin treatment," says first author Dr. Michael Leutner, MSc PhD (Department of Internal Medicine 3, Division of Endocrinology and Metabolism, Medical University of Vienna), who discusses the details of his study with Dr. Paul Studenic in this podcast.
Read the paper: https://ard.bmj.com/content/78/12/1706

A prediction score for individuals at risk to develop rheumatoid arthritis

In this podcast recorded at the ACR meeting 2019, Dr. Caroline Ospelt speaks to Prof. Anca Catrina and Dr. Aase Hensvold both of the Division of Rheumatology at the Department of Medicine located at the Karolinska Institute in Stockholm Sweden.
Hensvold et al. developed a prediction score by combining several clinical and blood-based markers that could be useful in predicting which patients with auto-antibodies and musculoskeletal symptoms develop ultrasound-detectable arthritis. These are the first results of an ongoing study on individuals at-risk for rheumatoid arthritis.

Prediction of radiographic progression using synovitis characteristics

Dr. Felice Rivellese from the Center of Experimental Medicine and Rheumatology at the Queen Mary University in London discusses the results of his presentation at the ACR 2019 with Dr. Caroline Ospelt. In a subanalysis of the pathobiology of the Early Arthitis Cohort (PEAC), Rivellese at al could show that B cell-rich synovitis is associated with disease severity and radiographic progression, in particular, if B cell infiltrates persist after cDMARD treatment.